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Activated by the antibiotic rifampicin and different plant metabolites, like hyperforin, guggulipid, colupulone, and isoflavones. Response to certain ligands is species-precise. Activated by The natural way taking place steroids, which include pregnenolone and progesterone. Binds to a response factor inside the promoters with the CYP3A4 and ABCB1/M